Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Kovner Bruce
  2. Issuer Name and Ticker or Trading Symbol
SYNTA PHARMACEUTICALS CORP [SNTA]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director__X__ 10% Owner
_____ Officer (give title below)_____ Other (specify below)
(Last)
(First)
(Middle)
C/O CAXTON CORPORATION, 731 ALEXANDER ROAD, BLDG 2
3. Date of Earliest Transaction (Month/Day/Year)
11/12/2012
(Street)

PRINCETON, NJ 08540
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock 11/12/2012   P   27,200 A $ 6.8915 (1) 937,200 (2) I By KFO Holdings LLC (3)
Common Stock 11/14/2012   P   10,500 A $ 6.9532 (4) 947,700 I By KFO Holdings LLC (3)
Common Stock               7,096,852 (5) D  
Common Stock               125,000 I By Kovner 2011-A Investment Trust
Common Stock               125,000 I By Kovner 2011-B Investment Trust
Common Stock               125,000 I By Kovner 2011-C Investment Trust
Common Stock               125,000 I By Kovner 2011-D Investment Trust
Common Stock               475,000 I By Kovner 2012-A Synta Investment Trust
Common Stock               475,000 I By Kovner 2012-B Synta Investment Trust
Common Stock               475,000 I By Kovner 2012-C Synta Investment Trust
Common Stock               475,000 I By Kovner 2012-D Synta Investment Trust
Common Stock               7,761,716 I By CxSynta LLC (6)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares

Reporting Owners

Reporting Owner Name / AddressRelationships
 Director 10% Owner Officer Other
Kovner Bruce
C/O CAXTON CORPORATION
731 ALEXANDER ROAD, BLDG 2
PRINCETON, NJ 08540
  X   X    

Signatures

 /s/ Bruce Kovner  11/14/2012
**Signature of Reporting PersonDate

Explanation of Responses:

*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)The shares were purchased in multiple transactions at prices ranging from $6.86 to $6.96 per share. The price reported above is the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the staff of the SEC, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price within the range set forth above.
(2)Includes 910,000 shares of Common Stock reported incorrectly on a Form 4 filed on July 2, 2012 as directly owned by the Reporting Person. See Notes 3 and 5.
(3)These shares are owned directly by KFO Holdings LLC ("KFO") and indirectly by the Reporting Person as the sole member of KFO.
(4)The shares were purchased in multiple transactions at prices ranging from $6.92 to $6.98 per share. The price reported above is the weighted average purchase price. The Reporting Person hereby undertakes to provide upon request to the staff of the SEC, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price within the range set forth above.
(5)Excludes 910,000 shares of Common Stock previously reported incorrectly on a Form 4 filed July 2, 2012 as directly owned by the Reporting Person that are directly owned by KFO Holdings LLC and indirectly owned by the Reporting Person. See Notes 2 and 3.
(6)These shares are owned directly by CxSynta LLC and indirectly by the Reporting Person as chairman and sole shareholder of Caxton Corporation, the managing member of CxSynta LLC. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of the beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

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